Brain Tumour North West

Research Consortium

Lancashire Teaching Hospitals:  Aside from developing and maintaining the tissue bank, recent research has been directed at investigating the feasibility of bespoke chemotherapy using novel and established agents by in vitro assay of primary brain tumour cultures. We have also been studying the in vitro actions of temozolamide and the potential of serum biomarkers for detecting and monitoring brain tumours. These projects formed the basis of several MD projects for Neurosurgical Fellows attached to the department.  

The Walton Centre:  The neuropathology dept has an extensive diagnostic archive of tissue which has been used for research into the molecular genetics of brain tumours. Neurosurgeon, Mr Michael Jenkinson has an interest in treatment of metastatic brain tumours.  

University of Central Lancashire:  Researchers are involved in a range of projects including investigating the roles of telomerase and HSP90alpha in glioma development, tissue culture modelling of the blood brain barrier and studying tumour characterisitics by IR spectroscopy.  

University of Wolverhampton:  The research team is primarily involved in studying the molecular genetic abnormalities of low and high grade gliomas.

University of Liverpool:  Liverpool groups are investigating the molecular basis of drug resistance/sensitivity in paediatric and adult brain tumours and looking at differentiation of implanted primitive neural cell lines in chick embryos.

University of Manchester:  Manchester is well known for it leading edge imaging research. Professor Jackson's team has been developing innovative ways of interpreting MR data to provide more information on brain tumour angiogenesis and infiltration. Omar Pathmanaban is analysing the interaction between microglia (brain immune defence cells) and brain tumour initiating cells.